Duke Neurobiology

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Primary Secondary Positions

Primary Secondary Positions

Laboratory of James O. McNamara, M.D. MainLab PersonnelRecent Papers

Huang, Y.Z., Pan, E., Xiong, Z.Q., and McNamara, J.O.  Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber CA3 pyramid synapse. Neuron, 57:546-558, 2008. Highlighted in a preview written by Bai Lu and colleagues.

Bausch, S. B., He,S., Petrova, Y., Wang, X. M. and McNamara, J. O. (2006) Plasticity of both excitatory and inhibitory synapses is associated with seizures induced by removal of chronic blockade of activity in cultured hippocampus. Journal of Neurophysiology 96:2151-2167.

Loo, L.S and McNamara, J.O. (2006) Impaired volume regulation is the mechanism of excitotoxic sensitization to complement. Journal of Neuroscience 26:10177-10187.

McNamara, J.O., Huang, Y.Z., and Leonard, A.S. (2006) Molecular signaling mechanisms underlying epileptogenesis. Science's STKE 10 October 2006: re12.

Puranam, R. S., Jain, S., Kleindienst, A. M., Saxena, S., Kim, M. K., Changizi, B. K., Padma, M. V., Andrews, I., Elston, R. C., Tiwari, H. K., and McNamara, J. O. (2005) A locus for generalized tonic-clonic seizure susceptibility maps to chromosome 10q25-q26. Annals of Neurology 58(3):449-458.

Bausch S.B. and McNamara J.O. (2004) Contributions of mossy fiber and CA1 pyramidal cell sprouting to dentate granule cell hyperecitability in kainic acid-treated hippocampal slice cultures. J Neurophysiology 92(6): 3582-3595

Danzer, S.C. and J.O. McNamara (2004). Location of BDNF to distinct terminals of mossy fiber axons implies regulation of both excitation and feedforward inhibition of CA3 pyramidal cells. J Neuroscience 24(50):11346-55

He X.-P., Kotloski R., Nef S., Luikart B.W., Parada L.F., and McNamara J.O. (2004) Conditional Deletion of TrkB but Not BDNF Prevents Epileptogenesis in the Kindling Model. Neuron 43:31-42.

Xiong Z.Q., Qian W., Suzuki K., and McNamara J.O. (2003) Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration. J Neurosci 23: 955-960.
Danzer S.C., Crooks K.R.C., Lo D.C., and McNamara J.O. (2002) Increased expression of brain-derived neurotrophic factor induces formation of basal dendrites and axonal branching in dentate granule cells in hippocampal explant cultures. J Neurosci., 15:22(22):9754-9763

He X.P., Minichiello L., Klein R. and McNamara J.O. (2002) Immunohistochemical evidence of seizure-induced activation of trkB receptors in the mossy fiber pathway of adult mouse hippocampus. J. Neurosci., 22:7502-7508.

Xiong Z.Q. and McNamara J.O. (2002) Fleeting activation of ionotropic glutamate receptors sensitizes cortical neurons to complement attach. Neuron 36:363-374.