Duke Neurobiology
Main Faculty and Research Graduate Program Postdoctoral Program Calendar Directory
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Laboratory of Sidney A. Simon, Ph.D.MainLab PersonnelRecent Papers
Rawicz, W.W, Smith, B., McIntosh, TJ, Simon, SA, Evans, EA (2008) Elasticity, permeability, and strength of lipid membranes containing raft microdomains. Biophysics J. (in press).
Tong, J., Nguyen L, Vidal, A., Simon, SA, Skene, J. H. P. and McIntosh, T. J. (2008) Role of GAP-43 in Sequestering Phosphatidylinositol 4,5-Bisphosphate (PIP2) to Raft Bilayers. Biophys. J.94 125-133.
de Araujo, Ivan E., Albino J. Oliveira-Maia, Tatyana D. Sotnikova, Raul R. Gainetdinov, Marc G. Caron, Miguel A. L. Nicolelis and Sidney A. Simon (2008) Reward in the absence of taste receptor signaling. Neuron (in review)
Costa, R. M., Gutierrez, R., Kloth, A. D., Coelho, M., de Araujo, I. E., Gainetdinov, R.R., Caron, M.G., Nicolelis, M. A. L. and Simon, S. A. (2007) Dopamine modulates the updating of tastant values. Genes, Brain & Behavior 6: 314-320.
Liu L, Chen L, Liedtke W, Simon SA (2007) Changes in Osmolality Sensitize the Response to Capsaicin in Trigeminal Sensory Neurons. J Neurophysiol 97: 2001-2015.
McIntosh, T.J. and Simon, S.A. (2007) Bilayers as Protein Solvents: Role of Bilayer Structure and Elastic Properties. J. Gen. Physiol. 130: 225-227. Published online Jul 16 2007, 10.1085/jgp.200709841.
Oliveira-Maia, AJ, Simon SA and Nicolelis, MAL (2007) Ensemble Measurements of Taste-Reward Pathways from Behaving Animals. In Frontiers in Neural Ensemble Recordings . In: Methods for Neural Ensemble Recordings, 2nd Edition (Nicolelis, MAL ed), pp 189-218: CRC Press. Boca Raton, Fl.
Riera, C. E. Vogel, H., Simon S. A. & le Coutre, J. (2007) Artificial Sweeteners and Salts Producing a Metallic Taste Sensation activate TRPV1 Receptors. Am J. Physiology 293: R626-R634.
Soares, E, Stapleton, J. R., Fitzsimmons, N., Rodriguez, A., Oliveria, L., Nicolelis, M. A. L. and Simon, S.A. (2007) Behavioral and neural responses to gustatory stimuli delivered non-contingently through intraoral cannulas . Physiology and Behavior 92(4):629-642.
Stapleton, JR, Lavine, ML., Nicolelis MAL and Simon, SA (2007) Ensembles of gustatory cortical neurons anticipate and discriminate between tastants in a single lick. Frontiers of Neuroscience 1: 161-174.
de Araujo, I. E., Nicolelis, M.A.L. and Simon, S. A. (2007) Evolution of Gustation. In: Volume 4 329-336.- Evolution of Nervous System in Mammals. Elsevier. Ed Jon Kaas.
Gutiérrez, R., Carmena, J. M., Nicolelis, M.A. L. & Simon, S. A. (2006) Orbitofrontal ensemble activity predicts licking and distinguishes among rewards. J. Neurophysiol. 95: 119-133.
Liu L. , Yang , T. M., Liedtke, W. and Simon, S.A. (2006) Chronic IL-1 signaling potentiates voltage dependent sodium currents in trigeminal nociceptive neurons . J. Neurophysiol. 95: 1478-1490.
Markin VS, Shlyonsky VG, Simon SA, Benos DJ, Ismailov II. (2006) Mechanosensitivity of gramicidin a channels in bulged bilayer membranes at constant tension. Biofizika 51: 1014-1018.
McIntosh, T. J. and Simon, S.A. (2006) Roles of Bilayer Material Properties in Function and Distribution of Membrane Proteins. Annu. Rev. Biophys. Biomol. Struct. 35: 177-198.
Rosenbaum, T. and Simon, S.A. (2006) TRPV1 Receptors and Signal Transduction. In "TRP ion channel function in sensory transduction and cellular signaling cascades" Ed. W. Liedtke and S Heller CRC Press LLC of Taylor and Francis Books, Inc., (Boca Raton, Fl), Chapter 5, pages 69-84.
Shlyonsky VG, Markin VS, Andreeva I, Pedersen SE, Simon SA, Benos DJ, Ismailov II. (2006) Role of membrane curvature in mechanoelectrical transduction: ion carriers, nonactin and valinomycin, sense changes in integral bending energy. Biochem Biophys Acta 1758: 1723–1731.
Simon SA, de Araujo IE, Gutierrez R, Nicolelis MAL. (2006) The neural mechanisms of gustation. Nature Rev Neurosci 7: 890-901.
Stapleton, J. R., Levine, M. , Wolpert, R. Nicolelis, MAL, Simon, S.A. (2006) Rapid taste responses in the gustatory cortex during licking. J. Neuroscience 26: 4126-4138.
Zampighi, G.A., Zampighi, L.M., Fain N., Lanzavecchia, S., Simon, S.A., Wright, E. M (2006) Docked synaptic vesicles are hemi-fused with the active zone. Biophysical J. 91: 2910-2918.
de Araujo IE, Nicolelis MALN and Simon SA (2006) Evolution of Gustation. Volume 4 - Evolution of Nervous System. Ed. John Kaas. Elsevier.
de Araujo, I. E, Gutierrez, R., Pereira Jr, A., Nicolelis MAL and Simon, S.A. (2006) Neural Ensemble Coding Predicts Satiety States. Neuron 51: 483-494.
Allende D, Simon SA and McIntosh TJ (2005) Melittin-induced bilayer leakage depends on lipid material properties; evidence for toroidal pores. Biophys. J. 88: 1-10.
Costa RM, Liu L, Nicolelis MAL, Simon SA (2005) Gustatory effects of capsaicin that are independent of TRPV1 receptors. Chem. Senses 30: i198-i200.
Lu G, Henderson D, Liu L, Reinhart PH, Simon SA. TRPV1b: a Functional Human Vanilloid Receptor Splice Variant. Mol Pharmacol. 2005 Jan 11; [Epub ahead of print]
Simon SA, and IE de Araujo (2005) The salty and burning taste of capsaicin. J Gen. Physiol. Jun;125(6):531-4.
Agopyan N, J Head, S Yu, and SA Simon (2004) TRPV1 receptors mediate PM-induced apoptosis. Am J Physiol Lung Cell Mol Physiol. 286(3):L563-L572.
Liedtke W and SA Simon (2004) A possible role for TRPV4 receptors in asthma Am. J. Physiol. Lung & Molecular Physiology 287: L269-L271.
Liu L, W Zhu, Z-S Zhang, T Yang, A Grant, G Oxford, and SA Simon (2004) Nicotine inhibits voltage-dependent sodium channels and sensitizes vanilloid receptors. J. Neurophysiology;91(4):1482-1491
Liu L, T Yang, M Block, OS Andersen and SA Simon (2004) Voltage-gated ion channels in nociceptors: modulation by cGMP. J. Neurophysiol. 92: 2323-2332.
Liu L, T Yang, and SA Simon (2004) The protein tyrosine kinase inhibitor, genistein, decreases excitability of nociceptive neurons. Pain 112: 131-141.
Agopyan N, L Li, S Yu, and SA Simon (2003) Negatively charged 2 and 10 μm particles activate vanilloid receptors, cAMP and induce IL-6 release. Toxicology and Applied Pharmacology 186: 63-76.
Agopyan N, T Bhatti, S Yu and SA Simon (2003) Vanilloid receptor activation by 2 and 10 μm particles induce apoptosis in human lung cells. Toxicology and Applied Pharmacology. 192: 21-35.
Allende D, A Vidal, SA Simon and TJ McIntosh (2003) Bilayer interfacial properties modulate the binding of amphipathic peptides. Chem. Phys. Lipids 122: 65-76.
Liu L and SA Simon (2003) Modulation of IA Currents by Capsaicin in Rat Trigeminal Ganglion Neurons J.Neurophysiol. 89: 1387-1401.
McIntosh TJ, A Vidal and SA Simon (2003) Sorting of lipids and transmembrane peptides between detergent soluble bilayers and detergent resistant rafts. Biophysical Journal 85: 1656-1666.
Simon SA, L Liu, and RP Erickson (2003) Neuropeptides modulate chorda tympani responses in a tastant specific manner. Am. J. Physiol.284: R1494-R1505
Spray DC and SA Simon (2003) “Thermoreceptors” in Encyclopedia of Neuroscience, 3d Edition (on CD ROM). Ed. G. Adelman and B.H. Smith. Oxford Press
Gandhavadi M, D Allende, A Vidal, SA Simon and TJ McIntosh (2002) Structure, composition, and peptide binding properties of detergent soluble bilayers and detergent resistant rafts. Biophysical J. 82: 1469-1482.
Katz DB, MAL Nicolelis and SA Simon (2002) Gustatory coding is dynamic and distributed. Curr Opin in Neurosci. 12: 448-454.
Katz DB, SA Simon and MAL Nicolelis (2002) Taste specific neuronal ensembles from the gustatory cortex of awake rats. J. Neurosci. 22: 1850-1857.
McIntosh TJ and SA Simon (2002) The Energetics of Peptide-Lipid Interactions: Modulation by Interfacial Dipoles and Cholesterol. In Peptide –Lipid interactions. Ed. Simon, S. A. and McIntosh, T. J. Academic Press, San Diego (pp. 309-338).
Simon SA (2002) Interactions between salt and acid stimuli: a lesson in gustation from simultaneous epithelial and neural recordings. J. Gen. Physiol. 12: 1-5.
Simon SA and MAL Nicolelis (Eds) (2002) Methods in Chemosensory Research. CRC Press Inc, Boca Raton FL.
Simon SA and TJ McIntosh (Eds.) (2002) Peptide-Lipid Interactions. Academic Press: San Diego, CA.